Publications / Scientific Presentations
Publications
Evaluation of brain activation related to resting pain using functional magnetic resonance imaging in cynomolgus macaques undergoing knee surgery
Hatsumi Ichinose , Takahiro Natsume , Mizuho Yano , Yuji Awaga , Mitsuru Hanada , Hiroyuki Takamatsu , Yukihiro Matsuyama (2024)
Journal of Orthopaedics on ScienceDirect; Volume 52, June 2024, Pages 12-16 (2024)
Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase.
Takahiro Hasegawa, Koji Akeda, Junichi Yamada, Koki Kawaguchi, Norihiko Takegami, Tatsuhiko Fujiwara, Takahiro Natsume, Koichiro Ide, Yukihiro Matsuyama, Akihiro Sudo (2023)
Arthritis Research & Therapy volume 25, Article number: 216 (2023)
Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation.
Murata, K., Nozawa, K., Matsushita, M., Yamashita, A., Fujii, R., Awaga, Y., Hama, A., Natsume, T., Yoshida, G., Matsuyama, Y., Takamatsu, H.
Neural Regeneration Research. March 15, 2023. doi: 10.4103/1673-5374.371382.
Regional brain activation during rectal distention and attenuation with alosetron in a nonhuman primate model of irritable bowel syndrome.
Fujii, R., Awaga, Y., Nozawa, K., Matsushita, M., Hama, A., Natsume, T., Takamatsu, H.
FASEB Bioadv. 2022 Aug 30;4(11):694-708. doi.org/10.1096/fba.2022-00048.
Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke.
Liston, T.E,. Hama, A., Boltze, J., Poe, R.B., Natsume, T., Hayashi, I., Takamatsu, H., Korinek, W.S. , Lechleiter, J.D.
Stroke. 2022 Jan;53(1):238-248. doi: 10.1161/STROKEAHA.121.036396.
Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury.
Hama, A., Yano, M., Sotogawa, W., Fujii, R., Awaga, Y., Natsume, T., Hayashi, I., Takamatsu, H.
Mol Pain. 2021 Jan-Dec;17:17448069211008697. doi.org/10.1177/17448069211008697
A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography.
Takahashi, N., Matsunaga, N., Natsume, T., Kitazawa, C., Itani, Y., Hama, A., Hayashi, I., Shimazawa, M., Hara, H., Takamatsu, H.
Heliyon. 2021 Apr 6;7(4):e06701. doi.org/10.1016/j.heliyon.2021.e06701
Exploratory clinical characterization of experimentally-induced ulcerative colitis nonhuman primates.
Takahashi, N., Kitazawa, C., Itani, Y., Awaga, Y., Hama, A., Hayash,i I., Takamatsu, H.
Heliyon. 2020 Jan 9;6(1):e03178. doi.org/10.1016/j.heliyon.2020.e03178.
Pharmacologic modulation of noxious stimulus-evoked brain activation in cynomolgus macaques observed with functional neuroimaging.
Shirai, T., Yano, M., Natsume, T., Awaga, Y., Itani, Y., Hama, A., Matsuda, A., Takamatsu, H.
J Am Assoc Lab Anim Sci. 2020 Jan 1;59(1):94-103. doi.org/10.30802/AALAS-JAALAS-18-000143.
Distinguishing analgesic drugs from non-analgesic drugs based on brain activation in macaques with oxaliplatin-induced neuropathic pain.
Shidahara, Y., Natsume, T., Awaga, Y., Ogawa, S., Yamoto, K., Okamoto, S., Hama, A., Hayashi, I., Takamatsu, H., Magata, Y.
Neuropharmacology. 2019 May 1;149:204-211. doi.org/10.1016/j.neuropharm.2019.02.031.
Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.
Yano, M., Matsuda, A., Natsume, T., Ogawa, S., Awaga, Y., Hayashi, I., Hama, A., Takamatsu, H.
Hum Reprod. 2019 Mar 1;34(3):469-478. doi.org/10.1093/humrep/dey383.
Pain-related behavior and brain activation in a cynomolgus macaque model of postoperative pain.
Hama, A., Natsume, T., Ogawa, S., Awaga, Y., Hayashi, I., Matsuda, A., Takamatsu, H.
CNS Neurol Disord Drug Targets. 2018;17(5):348-360. doi: 10.2174/1871527317666180515121350.
Gaps in understanding mechanism and lack of treatments: potential use of a nonhuman primate model of oxaliplatin-induced neuropathic pain.
Hama, A., Natsume, T., Ogawa, S., Higo, N., Hayashi, I., Takamatsu, H.
Pain Res Manag. 2018 May 2;2018:1630709. doi: 10.1155/2018/1630709.
Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
Nagasaka, K., Yamanaka, K., Ogawa, S., Takamatsu, H., Higo, N.
Sci Rep. 2017 Jun 27;7(1):4305. doi: 10.1038/s41598-017-04677-7.
Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients.
Saito, Y., Akazawa-Ogawa, Y., Matsumura A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Mita, Y., Shichiri, M., Hisahara, S., Hara, Y., Fujimura, H., Takamatsu, H., Hagihara, Y., Yoshida, Y., Hamakubo, T., Kusunoki, S., Shimohama, S. & Noguchi, N.
Sci Rep. 2016 Jul 29;6:30793.doi: 10.1038/srep30793.
Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis.
Ogawa, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.
Eur J Pharmacol. 2016 Sep 5;786:179-185. doi: 10.1016/j.ejphar.2016.06.008.
Knee osteoarthritis pain following medial meniscectomy in the nonhuman primate.
Ogawa, S., Awaga, Y., Takashima, M. Hama, A., Matsuda, A., Takamatsu, H.
Osteoarthritis Cartilage. 2016 Jul;24(7):1190-9. doi: 10.1016/j.joca.2016.02.006.
Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity.
Shidahara, Y., Ogawa, S., Nakamura, M., Nemoto, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.
Pharmacol Res Perspect. 2016 Feb 8;4(1):e00216. doi: 10.1002/prp2.216.
Chemotherapy-induced peripheral neuropathic pain and rodent models.
Hama, A., Takamatsu, H.
CNS Neurol Disord Drug Targets. 2016;15(1):7-19. doi: 10.2174/1871527315666151110125325.
Prasugrel reduces ischaemic infarct volume and ameliorates neurological deficits in a non-human primate model of middle cerebral artery thrombosis.
Tomizawa, A., Ohno, K., Jakubowski, J.A., Mizuno, M., Sugidachi, A.
Thromb Res. 2015 Dec;136(6):1224-30. doi: 10.1016/j.thromres.2015.09.013.
SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates.
Sawada, H., Nishimura N., Suzuki, E., Zhuang, J., Hasegawa, K., Takamatsu, H., Honda, K., Hasumi, K.
J Cereb Blood Flow Metab.. 2014 Feb;34(2):235-41. doi: 10.1038/jcbfm.2013.191.
Beyond rodent models of pain: non-human primate models for evaluating novel analgesic therapeutics and elaborating pain mechanisms.
Hama, A., Toide, K., Takamatsu, H.
CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1257-70. doi: 10.2174/18715273113129990111.
Scientific presentations
Visualizing pain using functional MRI (fMRI). (Japanese language)
Hama
49th Annual Meeting of the Japanese Society for Spine Surgery and Related Research; September 7, 2020; Kobe, Japan
Effect of prednisolone and vedolizumab on a newly developed chronic dextran sulfate sodium-induced colitis model in the nonhuman primate.
Takahashi et al.
Digestive Disease Week; 2019 May 18-21; San Diego, CA
Development of a macaque model of dry, nonexudative from age-related macular degeneration with geographic atrophy.
Takahashi et al.
The Association for Research in Vision and Ophthalmology; 2019 April 28 - May 2; Vancouver, British Columbia, Canada
Tracking of disease progression over time with optic nerve diffusion tensor imaging and retinal nerve fiber layer thickness in macaques with experimental glaucoma.
Takahashi et al.
The Association for Research in Vision and Ophthalmology; 2019 April 28 - May 2; Vancouver, British Columbia, Canada
Development of a chronic dextran sulfate sodium-induced colitis model in the nonhuman primate.
Takahashi et al.
United European Gastroenterology (UEG) Week Vienna 2018; 2018 October 20-24, Vienna, Austria
Pharmacological modulation of brain activation and pain-related behavior in cynomolgus macaque models of pain.
Hama et al.
17th World Congress on Pain; 2018 September 12-16; Boston, MA
Brain activation and pain-related behavior in a nonhuman primate model of experimental postoperative pain.
Yamoto et al.
WCP2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology; 2018 July 1-6; Kyoto, Japan
Pharmacological modulation of pain-related brain activation in nonhuman primates models of pain.
Yano et al.
Laboratory Animal Sciences 2018; 2018 Feb 7-8; LabRoots.
Neuroimaging of pain-related brain activation in nonhuman primates pain models.
Natsume et al.
American Association of Pharmaceutical Scientists 2017; 2017 Nov 12-15; San Diego, CA.
Pain-related behavior, pharmacological characterization and brain activation of nonhuman primates with naturally-occurring endometriosis.
Matsuda et al.
11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.
Evaluation of clinical analgesics in a nonhuman primate model of knee osteoarthritis.
Ogawa et al.
11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.
Natsume et al.
11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.
Brain activation and suppression with morphine in a nonhuman primate model of postoperative pain.
Hama et al.
11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.
Tanaka et al.
International Stroke Conference 2017; 2017 Feb 22-24; Houston, TX.
Hayashi et al.
Poster presented at: International Stroke Conference 2017; 2017 Feb 22-24; Houston, TX.
Suzuki et al.
Poster presented at: Society for Neuroscience 2016 Annual Meeting; 2016 Nov 12-16; San Diego, CA.
A nonhuman primate model of oxaliplatin-induced neuropathic pain.
Shidahara et al.
16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.
Pharmacological profile of a novel nonhuman primate model of knee osteoarthritis.
Ogawa et al.
16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.
Brain activity in a nonhuman primate model of oxaliplatin–induced neuropathic cold hypersensitivity.
Nagasaka et al.
16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.
Analgesic effects of the novel α2δ ligand mirogabalin (DS-5565) in spinal cord injury model rats.
Domon et al.
16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.
Differential effects of clinical analgesics in a nonhuman primate and rat model of oxaliplatin-induced peripheral neuropathy.
Shidahara et al.
The 89th Annual Meeting of The Japanese Pharmacological Society; 2016 Mar 9-11; Yokohama, Japan.
Pharmacological profile of knee osteoarthritis in a novel nonhuman primate model.
Ogawa et al.
The 89th Annual Meeting of The Japanese Pharmacological Society; 2016 Mar 9-11; Yokohama, Japan.
Pain-related behaviors in nonhuman primate models of knee osteoarthritis.
Nemoto et al
Society for Neuroscience 2015 Annual Meeting; 2015 Oct 17-21; Chicago, IL.
Shidahara et al.
Society for Neuroscience 2015 Annual Meeting; 2015 Oct 17-21; Chicago, IL.
A nonhuman primate model of knee osteoarthritis (OA) I: Medial meniscectomy (MMx)-induced OA.
Ogawa et al.
The 88th Annual Meeting of The Japanese Pharmacological Society; 2015 Mar 18-20; Nagoya, Japan.
A nonhuman primate model of knee osteoarthritis (OA) II: Monoiodoacetate-induced OA.
Nemoto et al.
The 88th Annual Meeting of The Japanese Pharmacological Society; 2015 Mar 18-20; Nagoya, Japan.
Testimonials
Noriyuki Higo, PhD
Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568, Japan
“HPR’s R&D team has amazing capabilities in conducting pharmacological studies, from behavioral characterization to MRI imaging. They have tremendously supported our research!”